Anti-CADM-140/MDA5 antibody and clinical subsets of dermatomyositis
نویسندگان
چکیده
منابع مشابه
Anti-CADM-140/MDA5 antibody and clinical subsets of dermatomyositis
The clinical features of dermatomyositis (DM) have a close relationship with myositis-specific antibodies. Clinically amyopathic dermatomyositis (CADM) is a subgroup of DM, which manifests as characteristic skin symptoms compatible with DM, such as Gottron's sign and heliotrope rash with no or mild muscle symptoms. Sometimes, a life-threatening rapidly progressing interstitial lung disease can ...
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Introduction Dermatomyositis is associated with an increased risk of malignancy, however, universal screening guidelines are not established. Recently the p155 antibody has been reported, along with an association with malignancy in dermatomyositis. The aim of this paper is to review the literature on the p155 antibody in DM and explore the implications this new marker may have in the clinical ...
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Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-...
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A man who was aged in his 80s was hospitalized in our department because of Gottron’s sign, muscle weakness and dysphagia. He was diagnosed with dermatomyositis (DM) based on the physical symptoms, muscle enzyme elevation and the results of electromyography. Immunoprecipitation for myositis-specific antibodies revealed bands of 140/155 kDa (Picture 1), which were compatible with anti-transcript...
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Anti-MDA5 antibody-positive patients with clinically amyopathic dermatomyositis (CADM) are at high risk of developing rapidly progressive interstitial lung disease (ILD), which is associated with a high mortality rate. Approximately half of the patients with ILD recover; however, the long-term clinical course of these patients has not been fully reported and is not completely understood. This r...
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2013
ISSN: 1880-9693,1880-8190
DOI: 10.2492/inflammregen.33.223